Scientific Study Proves Botox is Superior to Xeomin

By Warren B. Seiler III MD

This was recently proven in a landslide study comparing the two (A Multicenter, Randomised, Double-Blind Study to Evaluate the Efficacy of 20 Units of OnabotulinumtoxinA [Botox] in the Treatment of Glabellar Lines, When Compared to 30 Units of IncobotulinumtoxinA [Xeomin], by M. Moers-Carpi, MD et. al. and presented at the American Society for Dermatologic Surgery Annual Meeting.)

The results of this study showed three main things:

  1. It took 30 Units of Xeomin to equal the effect of 20 Units of Botox at 4 weeks
    At three months with this dosing, even the higher dose of Xeomin (50% more) was not nearly as effective or lasting as the smaller initial dose of Botox.
  2. This study was of the most trusted kind: “multicenter” meaning that it was proven at more than one practice and “randomized” meaning that the patients were randomly put into either group and they didn’t know which group they were in, nor did the physicians evaluating the results (keeps both sides honest) “double-blind” as above meaning that neither the patients nor the evaluators knew which ones received which injection
  3. Subjects were of a wide variation in age, sex, race and severity of condition and were excluded if they had any type of procedure in the last six months.

Take home points are that it takes more Xeomin to equal effects of Botox at 30 days but Xeomin doesn’t last as long. So you will spend more money initially and it will cost you more money in the long run. Hope this helps explain why Botox is simply a better treatment for expression lines.

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